Inside track weighs in with solution

Proteomics: The Nucleolus Weighs In

Numerous studies have indicated that the nucleolus is involved in a variety of cellular processes besides its well-known function in ribosome biosynthesis. A recent study describing the nucleolar proteome opens the way to new avenues of research on this important nuclear suborganelle.

Bone Weighs in on Obesity

Obesity, insulin resistance, and diabetes are related disorders of energy metabolism for which therapies are suboptimal. In this issue of Cell, Lee et al. (2007) demonstrate in mice that bone regulates the insulin/glucose axis and energy metabolism, providing a new framework for approaching common disorders of bioenergetics.

IRS weighs in on financial assistance.

n June 22, 2012, the Internal Revenue Service (IRS) issued a Notice of Proposed Rulemaking interpreting key provisions of Section 9007 of the Affordable Care Act, “Additional Requirements for Charitable Hospitals.” The proposed rules are related to financial assistance policies, limitations on charges, and billing and collection requirements under Section 501(r) of the Internal Revenue Code (IR...

The Inside Track: Privileged Neural Communication through Axon-Carrying Dendrites

Whether morphology tailors functional properties of pyramidal neurons is not completely understood. In this issue of Neuron, Thome et al. (2014) show that, in hippocampal pyramidal neurons, axons frequently originate from basal dendrites rather than the soma, constituting a "privileged" channel for synaptic inputs located in these axon-carrying dendrites.

Solution Strategies inside a Spectralelement Ocean